289800

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1234274..1234905 Replicon chromosome
Accession NZ_LR882498
Organism Mycobacterium tuberculosis variant microti strain Maus III isolate human

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag JN980_RS05795 Protein ID WP_003405820.1
Coordinates 1234274..1234585 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag JN980_RS05800 Protein ID WP_003405836.1
Coordinates 1234585..1234905 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN980_RS05775 1229756..1231180 - 1425 WP_003405805.1 class II fumarate hydratase -
JN980_RS05780 1231211..1232299 - 1089 WP_003898726.1 class II fructose-bisphosphatase -
JN980_RS05785 1232355..1232999 + 645 WP_202581996.1 DUF4245 domain-containing protein -
JN980_RS05790 1233006..1234162 - 1157 Protein_1141 AI-2E family transporter -
JN980_RS05795 1234274..1234585 - 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
JN980_RS05800 1234585..1234905 - 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
JN980_RS05805 1234915..1236440 + 1526 Protein_1144 carboxylesterase/lipase family protein -
JN980_RS05810 1236458..1237570 - 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
JN980_RS05815 1237580..1237837 - 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
JN980_RS05820 1237827..1239074 - 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
JN980_RS05825 1239071..1239709 - 639 WP_003898730.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T289800 WP_003405820.1 NZ_LR882498:c1234585-1234274 [Mycobacterium tuberculosis variant microti]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT289800 WP_003405836.1 NZ_LR882498:c1234905-1234585 [Mycobacterium tuberculosis variant microti]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References