Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 716624..717441 Replicon chromosome
Accession NC_020418
Organism Morganella morganii subsp. morganii KT

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A2C5TM43
Locus tag MU9_RS03355 Protein ID WP_004236532.1
Coordinates 716959..717441 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID J7TDK6
Locus tag MU9_RS03350 Protein ID WP_004236533.1
Coordinates 716624..716932 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU9_RS03325 711931..712137 - 207 WP_004236540.1 4-oxalocrotonate tautomerase family protein -
MU9_RS03330 712245..713237 - 993 WP_004236539.1 inner membrane protein YhjD -
MU9_RS03335 713649..714038 - 390 WP_004236536.1 DUF1090 domain-containing protein -
MU9_RS03340 714228..715070 + 843 WP_004236535.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
MU9_RS03345 715140..716492 + 1353 WP_004236534.1 glutathione-disulfide reductase -
MU9_RS03350 716624..716932 + 309 WP_004236533.1 DUF1778 domain-containing protein Antitoxin
MU9_RS03355 716959..717441 + 483 WP_004236532.1 GNAT family N-acetyltransferase Toxin
MU9_RS18755 717555..717695 - 141 WP_004236531.1 hypothetical protein -
MU9_RS03360 717692..718213 - 522 WP_015422407.1 isopentenyl-diphosphate Delta-isomerase -
MU9_RS03365 718341..718643 - 303 WP_004236529.1 ABC transporter substrate-binding protein -
MU9_RS03370 718853..719968 - 1116 WP_004236528.1 molybdenum cofactor guanylyltransferase MobA -
MU9_RS03375 720171..720440 + 270 WP_004240741.1 YihD family protein -
MU9_RS03380 720440..721435 + 996 WP_004236526.1 serine/threonine protein kinase -
MU9_RS03385 721454..722077 + 624 WP_004236525.1 thiol:disulfide interchange protein DsbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(36-135)

Antitoxin

Vibrio phage ICP1, Orf50

(21-94)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17729.48 Da        Isoelectric Point: 10.2370

>T28980 WP_004236532.1 NC_020418:716959-717441 [Morganella morganii subsp. morganii KT]
MQQHHDFTVFQSGEESLNHWLKTRALQNQQSGASRTFVVCHHNRIMAYYALSTGVITCSQAAGRFRRNMPPEIPVILPGR
LAVDESVKGRGIGRGLIKDAALRVLQAAGIVGIRGIVVRALSDNARRFYEHTGFMPSPADPMLLMITLRDLQLATGIYSE

Download         Length: 483 bp

>T28980 NC_020418:716959-717441 [Morganella morganii subsp. morganii KT]
TTGCAGCAGCATCATGATTTTACCGTTTTTCAGTCAGGTGAGGAGTCCCTTAACCATTGGCTGAAAACCCGCGCATTGCA
AAATCAGCAATCCGGAGCCTCACGGACATTTGTCGTCTGCCACCATAACCGGATAATGGCCTATTATGCATTATCGACAG
GCGTTATTACCTGTTCACAGGCGGCGGGTCGTTTCAGACGTAATATGCCCCCGGAAATTCCGGTTATCCTGCCGGGACGT
CTTGCTGTTGACGAAAGCGTAAAAGGCAGAGGGATCGGACGGGGTCTGATAAAAGATGCCGCACTGCGGGTCTTGCAGGC
GGCCGGGATTGTGGGTATCCGCGGTATTGTTGTCCGTGCTCTGTCTGATAATGCCAGACGTTTTTATGAGCATACCGGTT
TTATGCCGTCACCGGCTGACCCGATGCTGCTGATGATTACATTACGGGATCTGCAGCTGGCAACCGGCATCTATTCTGAA
TAG

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11499.15 Da        Isoelectric Point: 8.6397

>AT28980 WP_004236533.1 NC_020418:716624-716932 [Morganella morganii subsp. morganii KT]
MTKHTDEQHPVSGVNITRSTLNLRIKPEDKILIDRAAHAAGKNRTEFVLEAARRAAEETLADLRVIDVSTDVYQQFITRL
DMAPQSGEALKKTMLTKAPWEK

Download         Length: 309 bp

>AT28980 NC_020418:716624-716932 [Morganella morganii subsp. morganii KT]
ATGACAAAACACACAGATGAGCAGCATCCTGTGTCCGGCGTGAATATCACCCGTTCAACACTGAATTTACGCATCAAACC
GGAAGATAAAATTCTGATTGATCGCGCAGCGCATGCTGCCGGTAAAAACAGAACCGAGTTCGTACTGGAAGCTGCGCGGC
GTGCCGCCGAAGAAACACTGGCAGATTTACGGGTTATTGATGTCAGTACCGATGTCTATCAGCAGTTTATTACCAGACTG
GATATGGCACCACAGTCCGGTGAGGCGCTGAAGAAGACCATGCTGACGAAGGCGCCGTGGGAGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C5TM43

Antitoxin

Source ID Structure
AlphaFold DB J7TDK6

References