289797

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1016154..1016773 Replicon chromosome
Accession NZ_LR882498
Organism Mycobacterium tuberculosis variant microti strain Maus III isolate human

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag JN980_RS04765 Protein ID WP_003404726.1
Coordinates 1016339..1016773 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID G0TFQ5
Locus tag JN980_RS04760 Protein ID WP_003404724.1
Coordinates 1016154..1016333 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN980_RS04745 1011627..1013207 + 1581 WP_003909313.1 serine hydrolase -
JN980_RS04750 1013204..1015597 + 2394 WP_003898639.1 cation-translocating P-type ATPase -
JN980_RS04755 1015870..1016028 + 159 WP_003404720.1 hypothetical protein -
JN980_RS04760 1016154..1016333 + 180 WP_003404724.1 antitoxin Antitoxin
JN980_RS04765 1016339..1016773 + 435 WP_003404726.1 SRPBCC family protein Toxin
JN980_RS04770 1016871..1017644 + 774 WP_003404735.1 VOC family protein -
JN980_RS04775 1017709..1018158 + 450 WP_003404738.1 hypothetical protein -
JN980_RS04780 1018293..1018523 - 231 WP_003898642.1 hypothetical protein -
JN980_RS04785 1018690..1020198 - 1509 WP_003404742.1 carotenoid oxygenase family protein -
JN980_RS04790 1020200..1021438 - 1239 WP_003404744.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T289797 WP_003404726.1 NZ_LR882498:1016339-1016773 [Mycobacterium tuberculosis variant microti]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6394.06 Da        Isoelectric Point: 4.3059

>AT289797 WP_003404724.1 NZ_LR882498:1016154-1016333 [Mycobacterium tuberculosis variant microti]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLQDAASNVVGMSDQQS

Download         Length: 180 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G0TFQ5

References