Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 696312..696958 Replicon chromosome
Accession NZ_LR882498
Organism Mycobacterium tuberculosis variant microti strain Maus III isolate human

Toxin (Protein)


Gene name vapC Uniprot ID O07783
Locus tag JN980_RS03095 Protein ID WP_003403122.1
Coordinates 696312..696704 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ86
Locus tag JN980_RS03100 Protein ID WP_003403125.1
Coordinates 696701..696958 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN980_RS03080 691974..693500 + 1527 WP_003403112.1 virulence factor Mce family protein -
JN980_RS03085 693563..694705 + 1143 WP_193441967.1 virulence factor Mce family protein -
JN980_RS03090 694710..696260 + 1551 WP_003403119.1 MCE family protein -
JN980_RS03095 696312..696704 - 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 Toxin
JN980_RS03100 696701..696958 - 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 Antitoxin
JN980_RS03105 697141..698376 - 1236 WP_003403128.1 ATP-binding protein -
JN980_RS03110 698627..699040 - 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin -
JN980_RS03115 699037..699273 - 237 WP_003403139.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
JN980_RS03120 699377..699883 - 507 WP_003900973.1 two component system sensor kinase HK1 -
JN980_RS03125 699997..700527 - 531 WP_003917320.1 two component system sensor kinase HK2 -
JN980_RS03130 700511..701206 - 696 WP_003918099.1 two-component system response regulator TcrA -
JN980_RS03135 701329..701640 + 312 WP_003403164.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14080.08 Da        Isoelectric Point: 4.6558

>T289786 WP_003403122.1 NZ_LR882498:c696704-696312 [Mycobacterium tuberculosis variant microti]
VNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGVLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAW
ALLVSKLRAAKLRVPINDSWIAATAVAHGIAILTQDNDYAAMPDVEVITI

Download         Length: 393 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9681.06 Da        Isoelectric Point: 7.0175

>AT289786 WP_003403125.1 NZ_LR882498:c696958-696701 [Mycobacterium tuberculosis variant microti]
MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRRRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTT
DDVRW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F8V4

Antitoxin

Source ID Structure
AlphaFold DB G0TQ86

References