Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | pezAT/zeta-ParD |
Location | 445508..446519 | Replicon | chromosome |
Accession | NZ_LR882498 | ||
Organism | Mycobacterium tuberculosis variant microti strain Maus III isolate human |
Toxin (Protein)
Gene name | pezT | Uniprot ID | L7N5R2 |
Locus tag | JN980_RS01905 | Protein ID | WP_003401859.1 |
Coordinates | 445508..446101 (-) | Length | 198 a.a. |
Antitoxin (Protein)
Gene name | pezA | Uniprot ID | O53702 |
Locus tag | JN980_RS01910 | Protein ID | WP_003401860.1 |
Coordinates | 446130..446519 (-) | Length | 130 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JN980_RS01885 | 441157..442539 | + | 1383 | WP_105799635.1 | magnesium transporter | - |
JN980_RS01890 | 442551..443585 | - | 1035 | WP_003401856.1 | class II fructose-bisphosphate aldolase | - |
JN980_RS01895 | 443681..444364 | + | 684 | WP_003401857.1 | VTT domain-containing protein | - |
JN980_RS01900 | 444353..445483 | - | 1131 | WP_003401858.1 | hypothetical protein | - |
JN980_RS01905 | 445508..446101 | - | 594 | WP_003401859.1 | zeta toxin family protein | Toxin |
JN980_RS01910 | 446130..446519 | - | 390 | WP_003401860.1 | hypothetical protein | Antitoxin |
JN980_RS01915 | 446600..447811 | - | 1212 | WP_105799636.1 | VWA domain-containing protein | - |
JN980_RS01920 | 447817..448419 | - | 603 | WP_003898417.1 | SRPBCC family protein | - |
JN980_RS01925 | 448433..449329 | - | 897 | WP_003401863.1 | MoxR family ATPase | - |
JN980_RS01930 | 449326..449919 | - | 594 | WP_003401864.1 | NTP transferase domain-containing protein | - |
JN980_RS01935 | 449916..450671 | - | 756 | WP_003401865.1 | XdhC family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 198 a.a. Molecular weight: 21344.53 Da Isoelectric Point: 10.5018
>T289784 WP_003401859.1 NZ_LR882498:c446101-445508 [Mycobacterium tuberculosis variant microti]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA
Download Length: 594 bp
Antitoxin
Download Length: 130 a.a. Molecular weight: 13648.21 Da Isoelectric Point: 6.0829
>AT289784 WP_003401860.1 NZ_LR882498:c446519-446130 [Mycobacterium tuberculosis variant microti]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP
Download Length: 390 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BRU8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BRT0 |