Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3114106..3114676 Replicon chromosome
Accession NZ_LR882497
Organism Mycobacterium tuberculosis variant microti strain Maus IV isolate human

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag JN995_RS14600 Protein ID WP_003414166.1
Coordinates 3114106..3114462 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag JN995_RS14605 Protein ID WP_003901465.1
Coordinates 3114446..3114676 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN995_RS14580 3109558..3111246 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
JN995_RS14585 3111250..3111576 - 327 WP_003414157.1 hypothetical protein -
JN995_RS14590 3111749..3112336 + 588 WP_003914429.1 DUF3558 family protein -
JN995_RS14595 3112355..3114004 + 1650 WP_105799646.1 CocE/NonD family hydrolase -
JN995_RS14600 3114106..3114462 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
JN995_RS14605 3114446..3114676 - 231 WP_003901465.1 antitoxin MazE Antitoxin
JN995_RS14610 3114719..3115762 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
JN995_RS14615 3115953..3116228 + 276 WP_003911993.1 DUF1778 domain-containing protein -
JN995_RS14620 3116404..3116658 - 255 WP_003917684.1 hypothetical protein -
JN995_RS14625 3116806..3117210 + 405 WP_003414181.1 hypothetical protein -
JN995_RS14630 3117207..3117398 + 192 WP_003414184.1 hypothetical protein -
JN995_RS14635 3117462..3118751 + 1290 Protein_2887 transposase family protein -
JN995_RS14640 3118985..3119242 + 258 WP_003899489.1 hypothetical protein -
JN995_RS14645 3119347..3119658 + 312 WP_003414190.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T289770 WP_003414166.1 NZ_LR882497:c3114462-3114106 [Mycobacterium tuberculosis variant microti]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT289770 WP_003901465.1 NZ_LR882497:c3114676-3114446 [Mycobacterium tuberculosis variant microti]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
PDB 7DU5
PDB 6KYT
AlphaFold DB A0A7U4FBW3

References