Detailed information of TA system TA028977

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 2493229..2493803
• Replicon: chromosome
• Accession: NC_020304
• Organism: Desulfocapsa sulfexigens DSM 10523

Toxin (Protein)

• Gene name: relE
• Uniprot ID: M1PGJ6
• Locus tag: UWK_RS11075
• Protein ID: WP_015404458.1
• Coordinates: 2493229..2493525 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M1PQU6
• Locus tag: UWK_RS11080
• Protein ID: WP_015404459.1
• Coordinates: 2493522..2493803 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
UWK_RS19600	2488350..2488511	-	162	WP_015404453.1	hypothetical protein	-
UWK_RS11055	2488705..2489295	-	591	WP_015404454.1	hypothetical protein	-
UWK_RS11060	2489431..2490705	-	1275	WP_015404455.1	sodium:proton antiporter	-
UWK_RS11065	2490778..2492205	-	1428	WP_015404456.1	carbonic anhydrase	-
UWK_RS11070	2492278..2492844	-	567	WP_015404457.1	CBS domain-containing protein	-
UWK_RS11075	2493229..2493525	-	297	WP_015404458.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
UWK_RS11080	2493522..2493803	-	282	WP_015404459.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
UWK_RS11085	2494067..2495620	-	1554	WP_015404460.1	IS1182 family transposase	-
UWK_RS11090	2496345..2497694	+	1350	WP_015404462.1	group II intron reverse transcriptase/maturase	-
UWK_RS11100	2497878..2498318	-	441	WP_015404463.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-76)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11313.33 Da
• Isoelectric Point: 7.0125

>T28977 WP_015404458.1 NC_020304:c2493525-2493229 [Desulfocapsa sulfexigens DSM 10523]
MKITWSPLAIDRASEIAEYISLDNPTAASKWIDDIFEKVLILNSMPKMGRTVPEINRKEIRGIIFGNYRIIYRIEEMSIA
ILTIRHTKQILPVDELIA

Nucleotide

• Length: 297 bp

>T28977 NC_020304:c2493525-2493229 [Desulfocapsa sulfexigens DSM 10523]
ATGAAAATAACCTGGTCTCCATTAGCTATTGATAGAGCCTCGGAAATTGCAGAATATATTTCATTAGACAATCCTACGGC
TGCATCAAAATGGATTGATGATATTTTTGAAAAAGTTCTAATCTTAAATTCAATGCCCAAAATGGGCCGTACTGTTCCAG
AAATAAACAGAAAAGAAATAAGAGGAATTATTTTTGGTAATTATCGAATAATTTACCGAATAGAAGAGATGAGTATTGCC
ATTCTTACTATCCGTCACACTAAGCAAATACTACCTGTAGATGAACTAATAGCATAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10473.14 Da
• Isoelectric Point: 9.7262

>AT28977 WP_015404459.1 NC_020304:c2493803-2493522 [Desulfocapsa sulfexigens DSM 10523]
MQRLRVDQDIRSMSEFRAGIASFLKQVHDTKRPLIITQHGKGAAVLLDVGEYEAMQEKIELLSDVQKAISQIENGEGVAH
KNAKDMILKRISK

Nucleotide

• Length: 282 bp

>AT28977 NC_020304:c2493803-2493522 [Desulfocapsa sulfexigens DSM 10523]
ATGCAAAGATTGAGAGTAGATCAAGATATACGTTCTATGTCAGAATTCAGGGCAGGAATAGCTTCTTTTCTTAAGCAAGT
CCACGATACTAAAAGACCACTAATTATTACTCAGCATGGCAAAGGTGCTGCTGTATTGTTGGACGTAGGCGAATATGAAG
CTATGCAGGAAAAGATCGAATTGCTAAGTGATGTGCAAAAAGCAATTAGCCAAATTGAAAATGGAGAAGGAGTAGCACAC
AAAAACGCAAAGGATATGATCTTAAAGAGAATATCCAAATGA

Structures

Toxin

• AlphaFold DB: M1PGJ6

Antitoxin

• AlphaFold DB: M1PQU6