Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3074121..3074800 Replicon chromosome
Accession NZ_LR882497
Organism Mycobacterium tuberculosis variant microti strain Maus IV isolate human

Toxin (Protein)


Gene name vapC Uniprot ID P9WF90
Locus tag JN995_RS14380 Protein ID WP_003414059.1
Coordinates 3074121..3074537 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TF64
Locus tag JN995_RS14385 Protein ID WP_003414061.1
Coordinates 3074534..3074800 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN995_RS14360 3070173..3071075 - 903 WP_003900564.1 4-hydroxy-tetrahydrodipicolinate synthase -
JN995_RS14365 3071144..3071896 - 753 WP_003899465.1 FAD-dependent thymidylate synthase -
JN995_RS14370 3072140..3072415 - 276 WP_003414055.1 type I restriction endonuclease subunit S -
JN995_RS14375 3072412..3074034 - 1623 WP_003414057.1 type I restriction-modification system subunit M -
JN995_RS14380 3074121..3074537 - 417 WP_003414059.1 type II toxin-antitoxin system toxin ribonuclease C21 Toxin
JN995_RS14385 3074534..3074800 - 267 WP_003414061.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN995_RS14390 3074826..3075221 - 396 WP_003414064.1 type II toxin-antitoxin system VapC family toxin -
JN995_RS14395 3075218..3075487 - 270 WP_003414066.1 type II toxin-antitoxin system VapB family antitoxin -
JN995_RS14400 3075497..3076591 - 1095 WP_003414068.1 restriction endonuclease subunit S -
JN995_RS14405 3076588..3077007 - 420 WP_003414070.1 winged helix-turn-helix domain-containing protein -
JN995_RS14410 3077081..3077560 - 480 WP_003414073.1 dihydrofolate reductase -
JN995_RS14415 3077631..3078431 - 801 WP_003911953.1 thymidylate synthase -
JN995_RS14420 3078587..3079324 + 738 WP_003414079.1 dienelactone hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(16-56)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15773.00 Da        Isoelectric Point: 7.1294

>T289768 WP_003414059.1 NZ_LR882497:c3074537-3074121 [Mycobacterium tuberculosis variant microti]
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA

Download         Length: 417 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9493.77 Da        Isoelectric Point: 7.2783

>AT289768 WP_003414061.1 NZ_LR882497:c3074800-3074534 [Mycobacterium tuberculosis variant microti]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5SV2

Antitoxin

Source ID Structure
AlphaFold DB G0TF64

References