Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2812043..2812695 Replicon chromosome
Accession NZ_LR882497
Organism Mycobacterium tuberculosis variant microti strain Maus IV isolate human

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag JN995_RS12990 Protein ID WP_003412752.1
Coordinates 2812270..2812695 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag JN995_RS12985 Protein ID WP_003412749.1
Coordinates 2812043..2812264 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN995_RS12970 2810283..2810489 - 207 WP_003899347.1 hypothetical protein -
JN995_RS12975 2810625..2811248 + 624 WP_202582046.1 TIGR00725 family protein -
JN995_RS12980 2811238..2811990 + 753 WP_105799954.1 hypothetical protein -
JN995_RS12985 2812043..2812264 + 222 WP_003412749.1 antitoxin Antitoxin
JN995_RS12990 2812270..2812695 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
JN995_RS12995 2812718..2813899 - 1182 WP_003899351.1 2-oxo acid dehydrogenase subunit E2 -
JN995_RS13000 2813896..2814942 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
JN995_RS13005 2814953..2816056 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
JN995_RS13010 2816315..2817136 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
JN995_RS13015 2817133..2817690 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T289761 WP_003412752.1 NZ_LR882497:2812270-2812695 [Mycobacterium tuberculosis variant microti]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT289761 WP_003412749.1 NZ_LR882497:2812043-2812264 [Mycobacterium tuberculosis variant microti]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References