Detailed information of TA system TA028976

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacT-ataR/DUF1778(antitoxin)
• Location: 2002533..2003284
• Replicon: chromosome
• Accession: NC_020304
• Organism: Desulfocapsa sulfexigens DSM 10523

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: M1P4D0
• Locus tag: UWK_RS08900
• Protein ID: WP_015404039.1
• Coordinates: 2002533..2003009 (-)
• Length: 159 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: M1NF98
• Locus tag: UWK_RS08905
• Protein ID: WP_015404040.1
• Coordinates: 2002997..2003284 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
UWK_RS08880	1998435..1999175	+	741	WP_015404035.1	hypothetical protein	-
UWK_RS08885	1999168..1999773	+	606	WP_015404036.1	methyl-accepting chemotaxis protein	-
UWK_RS08890	1999766..2000302	+	537	WP_015404037.1	hypothetical protein	-
UWK_RS08895	2000346..2001674	-	1329	WP_167320736.1	undecaprenyl/decaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase	-
UWK_RS08900	2002533..2003009	-	477	WP_015404039.1	GNAT family N-acetyltransferase	Toxin
UWK_RS08905	2002997..2003284	-	288	WP_015404040.1	DUF1778 domain-containing protein	Antitoxin
UWK_RS08910	2003819..2004991	-	1173	WP_015404041.1	nucleotidyltransferase family protein	-
UWK_RS08915	2004978..2006087	-	1110	WP_015404042.1	UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)	-
UWK_RS08920	2006097..2006834	-	738	WP_015404043.1	WecB/TagA/CpsF family glycosyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (44-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (14-87)

Sequences

Toxin

Protein

• Length: 159 a.a.
• Molecular weight: 17222.90 Da
• Isoelectric Point: 9.8175

>T28976 WP_015404039.1 NC_020304:c2003009-2002533 [Desulfocapsa sulfexigens DSM 10523]
VGKISAPEQLTANHLLSGFDCGTVSLNEWLIHRALKNEQSGGSRTYVVCFKNQVIGYYALAAGSVARAEATNRIKKNMPD
PIPALVLGRLAVDCNWQGQNIGRGLLKDALARAINVSEQVGVRVIIVHVLNDKAEAFYRKHGFTNNNIVSNTLMLPLL

Nucleotide

• Length: 477 bp

>T28976 NC_020304:c2003009-2002533 [Desulfocapsa sulfexigens DSM 10523]
GTGGGAAAAATAAGCGCTCCTGAACAATTGACAGCGAATCACCTATTAAGTGGTTTTGATTGTGGAACAGTTTCACTCAA
CGAATGGCTTATCCACCGGGCATTGAAAAACGAACAGAGTGGCGGGTCACGCACGTATGTGGTTTGTTTTAAAAATCAGG
TGATAGGGTACTATGCTCTAGCTGCTGGAAGCGTTGCTCGTGCTGAAGCGACAAACCGCATAAAAAAGAATATGCCTGAT
CCTATCCCTGCTCTAGTGCTTGGTCGCTTGGCGGTTGATTGTAACTGGCAGGGGCAGAATATTGGCCGAGGTTTGTTAAA
AGATGCTCTTGCCCGAGCAATTAACGTTTCCGAACAGGTCGGTGTCCGTGTTATTATCGTCCATGTTCTTAATGATAAGG
CAGAAGCCTTTTATCGTAAACACGGCTTTACGAACAACAATATCGTCTCCAACACATTGATGCTTCCGTTGTTATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10854.50 Da
• Isoelectric Point: 8.7806

>AT28976 WP_015404040.1 NC_020304:c2003284-2002997 [Desulfocapsa sulfexigens DSM 10523]
MKPSNTTARRTSVISLRAFPEQRELIGQACAASHKKMTDFILEASCREAEQVLCDRRNFVLDDKAFSDFEKALETPLNEN
KAIRKLLLSKAPWEK

Nucleotide

• Length: 288 bp

>AT28976 NC_020304:c2003284-2002997 [Desulfocapsa sulfexigens DSM 10523]
ATGAAACCAAGTAACACAACAGCACGTCGCACATCTGTAATTAGTCTCCGTGCATTTCCGGAACAGAGGGAGCTGATTGG
TCAGGCTTGTGCTGCAAGTCACAAAAAGATGACCGATTTTATCCTTGAAGCGTCATGTCGTGAGGCTGAGCAAGTTTTGT
GTGATCGGCGTAATTTTGTCTTGGATGATAAAGCATTTTCTGATTTTGAGAAAGCTTTAGAAACGCCACTTAATGAAAAC
AAAGCTATCCGTAAGCTACTGTTATCAAAAGCACCGTGGGAAAAATAA

Structures

Toxin

• AlphaFold DB: M1P4D0

Antitoxin

• AlphaFold DB: M1NF98