289759

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2371917..2372612 Replicon chromosome
Accession NZ_LR882497
Organism Mycobacterium tuberculosis variant microti strain Maus IV isolate human

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag JN995_RS10910 Protein ID WP_003410811.1
Coordinates 2371917..2372351 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag JN995_RS10915 Protein ID WP_003410814.1
Coordinates 2372358..2372612 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN995_RS10900 2368071..2371112 + 3042 WP_003899171.1 DEAD/DEAH box helicase -
JN995_RS10905 2371105..2371938 + 834 WP_003899172.1 SWIM zinc finger family protein -
JN995_RS10910 2371917..2372351 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
JN995_RS10915 2372358..2372612 - 255 WP_003410814.1 antitoxin Antitoxin
JN995_RS10920 2372628..2372885 - 258 WP_003410816.1 hypothetical protein -
JN995_RS10925 2373833..2374129 + 297 WP_003410820.1 PE family protein -
JN995_RS10930 2374185..2374916 + 732 WP_003900467.1 PPE family protein -
JN995_RS10935 2375456..2376202 - 747 WP_003901330.1 proteasome subunit alpha -
JN995_RS10940 2376199..2377074 - 876 WP_003411023.1 proteasome subunit beta -
JN995_RS10945 2377071..2377265 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T289759 WP_003410811.1 NZ_LR882497:c2372351-2371917 [Mycobacterium tuberculosis variant microti]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT289759 WP_003410814.1 NZ_LR882497:c2372612-2372358 [Mycobacterium tuberculosis variant microti]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References