Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2235145..2235731 Replicon chromosome
Accession NZ_LR882497
Organism Mycobacterium tuberculosis variant microti strain Maus IV isolate human

Toxin (Protein)


Gene name mazF Uniprot ID G0TLY3
Locus tag JN995_RS10310 Protein ID WP_003410010.1
Coordinates 2235145..2235489 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL58
Locus tag JN995_RS10315 Protein ID WP_003410014.1
Coordinates 2235483..2235731 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN995_RS10275 2230345..2231256 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
JN995_RS10280 2231365..2231964 + 600 WP_003409989.1 L-lysine exporter -
JN995_RS10285 2232380..2232808 + 429 WP_003409992.1 cellulose-binding protein -
JN995_RS10290 2233579..2234139 - 561 WP_003410001.1 RES family NAD+ phosphorylase -
JN995_RS10295 2234136..2234477 - 342 WP_003410003.1 DUF2384 domain-containing protein -
JN995_RS10300 2234563..2234820 + 258 WP_003410006.1 hypothetical protein -
JN995_RS10305 2234721..2235056 - 336 WP_003410009.1 dehydrogenase -
JN995_RS10310 2235145..2235489 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 Toxin
JN995_RS10315 2235483..2235731 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family Antitoxin
JN995_RS10320 2235831..2238146 - 2316 WP_003899120.1 cation transporter ATPase CptG -
JN995_RS10325 2238143..2238415 - 273 WP_003410017.1 DUF1490 family protein -
JN995_RS10330 2238468..2238824 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -
JN995_RS10335 2238981..2239748 + 768 WP_003410019.1 hemerythrin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12230.12 Da        Isoelectric Point: 9.8887

>T289755 WP_003410010.1 NZ_LR882497:c2235489-2235145 [Mycobacterium tuberculosis variant microti]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL

Download         Length: 345 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9290.34 Da        Isoelectric Point: 4.3757

>AT289755 WP_003410014.1 NZ_LR882497:c2235731-2235483 [Mycobacterium tuberculosis variant microti]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5HK3
PDB 5HK0
PDB 5HKC

Antitoxin

Source ID Structure
PDB 7WJ0
PDB 7WNR
AlphaFold DB A0A7U4FAW9

References