Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2233579..2234477 Replicon chromosome
Accession NZ_LR882497
Organism Mycobacterium tuberculosis variant microti strain Maus IV isolate human

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag JN995_RS10290 Protein ID WP_003410001.1
Coordinates 2233579..2234139 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag JN995_RS10295 Protein ID WP_003410003.1
Coordinates 2234136..2234477 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN995_RS10265 2229262..2229915 - 654 WP_003409976.1 cutinase Cfp21 -
JN995_RS10270 2230030..2230260 + 231 WP_003409980.1 DUF167 domain-containing protein -
JN995_RS10275 2230345..2231256 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
JN995_RS10280 2231365..2231964 + 600 WP_003409989.1 L-lysine exporter -
JN995_RS10285 2232380..2232808 + 429 WP_003409992.1 cellulose-binding protein -
JN995_RS10290 2233579..2234139 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
JN995_RS10295 2234136..2234477 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
JN995_RS10300 2234563..2234820 + 258 WP_003410006.1 hypothetical protein -
JN995_RS10305 2234721..2235056 - 336 WP_003410009.1 dehydrogenase -
JN995_RS10310 2235145..2235489 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
JN995_RS10315 2235483..2235731 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
JN995_RS10320 2235831..2238146 - 2316 WP_003899120.1 cation transporter ATPase CptG -
JN995_RS10325 2238143..2238415 - 273 WP_003410017.1 DUF1490 family protein -
JN995_RS10330 2238468..2238824 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T289754 WP_003410001.1 NZ_LR882497:c2234139-2233579 [Mycobacterium tuberculosis variant microti]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT289754 WP_003410003.1 NZ_LR882497:c2234477-2234136 [Mycobacterium tuberculosis variant microti]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References