Detailed information of TA system TA028975

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 977786..978311
• Replicon: chromosome
• Accession: NC_020304
• Organism: Desulfocapsa sulfexigens DSM 10523

Toxin (Protein)

• Gene name: relE
• Uniprot ID: M1NCD0
• Locus tag: UWK_RS04285
• Protein ID: WP_015403120.1
• Coordinates: 977786..978070 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M1PCF7
• Locus tag: UWK_RS04290
• Protein ID: WP_015403121.1
• Coordinates: 978060..978311 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
UWK_RS04265	973137..973727	+	591	WP_015403116.1	carbonic anhydrase	-
UWK_RS04270	974013..975194	-	1182	WP_015403117.1	ATP-grasp domain-containing protein	-
UWK_RS04275	975706..976083	+	378	WP_015403118.1	hypothetical protein	-
UWK_RS04280	976512..977531	-	1020	WP_015403119.1	type I methionyl aminopeptidase	-
UWK_RS04285	977786..978070	-	285	WP_015403120.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
UWK_RS04290	978060..978311	-	252	WP_015403121.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
UWK_RS04295	978759..978980	-	222	WP_015403122.1	hypothetical protein	-
UWK_RS04300	978995..979882	-	888	WP_015403123.1	hypothetical protein	-
UWK_RS18200	980059..980826	-	768	WP_015403124.1	hypothetical protein	-
UWK_RS04310	980981..982366	-	1386	WP_015403125.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-76)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11165.18 Da
• Isoelectric Point: 10.7113

>T28975 WP_015403120.1 NC_020304:c978070-977786 [Desulfocapsa sulfexigens DSM 10523]
MSYKLKFLPTALKEWKKLDNTIQSQFKKKLKERLESPHVSGSRLSGFENHYKIKLRASGYRLVYEVVDEEVFVYVIAIGK
RDKNLVYKKAKKRK

Nucleotide

• Length: 285 bp

>T28975 NC_020304:c978070-977786 [Desulfocapsa sulfexigens DSM 10523]
ATGAGCTATAAATTAAAATTCCTCCCAACCGCCCTTAAGGAATGGAAAAAACTAGACAACACTATACAATCACAATTCAA
GAAAAAATTAAAAGAACGCCTAGAATCGCCACATGTTTCTGGTAGTCGCCTGTCTGGATTTGAGAACCACTACAAAATTA
AACTCAGAGCAAGCGGATACCGGCTTGTTTATGAAGTAGTTGATGAAGAAGTTTTTGTTTACGTAATTGCTATCGGCAAA
AGAGACAAAAATTTAGTCTATAAAAAGGCGAAAAAACGAAAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9212.48 Da
• Isoelectric Point: 4.2925

>AT28975 WP_015403121.1 NC_020304:c978311-978060 [Desulfocapsa sulfexigens DSM 10523]
MESVLASRSASISELKKNPSALIDQSDGEPIAILNHNKPTAYLIPAETYEALLERLEDHQLGIIVKEREIEKISAVEITL
DEL

Nucleotide

• Length: 252 bp

>AT28975 NC_020304:c978311-978060 [Desulfocapsa sulfexigens DSM 10523]
ATGGAATCAGTACTAGCAAGCCGCTCAGCAAGTATATCAGAATTAAAGAAAAACCCTTCTGCTTTGATAGATCAGTCAGA
TGGTGAACCAATCGCTATTCTCAATCACAACAAGCCGACTGCATATTTAATTCCAGCAGAAACATATGAAGCACTACTGG
AAAGACTAGAGGATCACCAACTAGGAATTATAGTAAAAGAAAGGGAAATTGAAAAAATCTCAGCTGTGGAAATTACACTA
GATGAGCTATAA

Structures

Toxin

• AlphaFold DB: M1NCD0

Antitoxin

• AlphaFold DB: M1PCF7