Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1970769..1971229 Replicon chromosome
Accession NZ_LR882497
Organism Mycobacterium tuberculosis variant microti strain Maus IV isolate human

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FB26
Locus tag JN995_RS09060 Protein ID WP_003408531.1
Coordinates 1970981..1971229 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag JN995_RS09055 Protein ID WP_003408528.1
Coordinates 1970769..1970981 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN995_RS09040 1967247..1968434 - 1188 WP_003898992.1 nitrate transporter NarK -
JN995_RS09045 1968721..1969005 + 285 WP_003408522.1 DUF1876 domain-containing protein -
JN995_RS09050 1969019..1970701 - 1683 WP_003898994.1 SulP family inorganic anion transporter -
JN995_RS09055 1970769..1970981 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN995_RS09060 1970981..1971229 + 249 WP_003408531.1 hypothetical protein Toxin
JN995_RS09065 1971237..1971975 + 739 Protein_1788 hypothetical protein -
JN995_RS09070 1972069..1973769 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
JN995_RS09075 1974054..1974455 - 402 WP_003408538.1 hypothetical protein -
JN995_RS09080 1974445..1975056 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8857.07 Da        Isoelectric Point: 3.9794

>T289749 WP_003408531.1 NZ_LR882497:1970981-1971229 [Mycobacterium tuberculosis variant microti]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYTGDDFACIDIRAVL
AG

Download         Length: 249 bp

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT289749 WP_003408528.1 NZ_LR882497:1970769-1970981 [Mycobacterium tuberculosis variant microti]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB26

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References