Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1950071..1950684 Replicon chromosome
Accession NZ_LR882497
Organism Mycobacterium tuberculosis variant microti strain Maus IV isolate human

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag JN995_RS08950 Protein ID WP_003408465.1
Coordinates 1950071..1950460 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag JN995_RS08955 Protein ID WP_003408469.1
Coordinates 1950457..1950684 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN995_RS08920 1945700..1946614 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
JN995_RS08925 1946617..1947447 + 831 WP_003408448.1 cyclase family protein -
JN995_RS08930 1947447..1947797 + 351 WP_003898986.1 cupin domain-containing protein -
JN995_RS08935 1947850..1948668 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
JN995_RS08940 1948682..1949461 + 780 WP_003408460.1 IclR family transcriptional regulator -
JN995_RS08950 1950071..1950460 - 390 WP_003408465.1 PIN domain-containing protein Toxin
JN995_RS08955 1950457..1950684 - 228 WP_003408469.1 antitoxin Antitoxin
JN995_RS08960 1950902..1952386 + 1485 WP_003408473.1 carboxylase -
JN995_RS08965 1952383..1953630 + 1248 WP_003408476.1 serine hydrolase -
JN995_RS08970 1953673..1954092 - 420 WP_105799667.1 hypothetical protein -
JN995_RS08975 1954082..1954792 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T289748 WP_003408465.1 NZ_LR882497:c1950460-1950071 [Mycobacterium tuberculosis variant microti]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT289748 WP_003408469.1 NZ_LR882497:c1950684-1950457 [Mycobacterium tuberculosis variant microti]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References