Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1696255..1696871 Replicon chromosome
Accession NZ_LR882497
Organism Mycobacterium tuberculosis variant microti strain Maus IV isolate human

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag JN995_RS07860 Protein ID WP_003407593.1
Coordinates 1696554..1696871 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag JN995_RS07855 Protein ID WP_003900349.1
Coordinates 1696255..1696557 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN995_RS07845 1692141..1693988 + 1848 WP_202582012.1 methylmalonyl-CoA mutase small subunit -
JN995_RS07850 1693989..1696241 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
JN995_RS07855 1696255..1696557 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
JN995_RS07860 1696554..1696871 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
JN995_RS07865 1696868..1697872 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
JN995_RS07870 1697925..1699214 + 1290 WP_202582139.1 serine hydrolase -
JN995_RS07875 1699287..1700060 - 774 WP_003912632.1 class I SAM-dependent methyltransferase -
JN995_RS07880 1700118..1700309 - 192 WP_003407609.1 dodecin family protein -
JN995_RS07885 1700340..1700564 - 225 WP_160522526.1 NUDIX domain-containing protein -
JN995_RS07890 1700834..1701862 + 1029 WP_003407612.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T289746 WP_003407593.1 NZ_LR882497:1696554-1696871 [Mycobacterium tuberculosis variant microti]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT289746 WP_003900349.1 NZ_LR882497:1696255-1696557 [Mycobacterium tuberculosis variant microti]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
PDB 5XE3
AlphaFold DB G0TJ73

References