Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 1549111..1550161 Replicon chromosome
Accession NZ_LR882497
Organism Mycobacterium tuberculosis variant microti strain Maus IV isolate human

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag JN995_RS07200 Protein ID WP_003407164.1
Coordinates 1549111..1549932 (+) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag JN995_RS07205 Protein ID WP_003407167.1
Coordinates 1549925..1550161 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN995_RS07180 1544660..1545322 - 663 WP_003407152.1 membrane protein -
JN995_RS07185 1545319..1546113 - 795 WP_031703329.1 hypothetical protein -
JN995_RS07190 1546404..1548365 - 1962 WP_202582006.1 SpoIIE family protein phosphatase -
JN995_RS07195 1548504..1548890 - 387 WP_003407162.1 anti-sigma-F factor antagonist RsfA -
JN995_RS07200 1549111..1549932 + 822 WP_003407164.1 GTP pyrophosphokinase family protein Toxin
JN995_RS07205 1549925..1550161 + 237 WP_003407167.1 hypothetical protein Antitoxin
JN995_RS07210 1550233..1551438 - 1206 WP_003918234.1 serine hydrolase -
JN995_RS07215 1551741..1552526 + 786 WP_003407180.1 lipoprotein LprF -
JN995_RS07220 1552722..1554191 + 1470 WP_105799839.1 fatty acid desaturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T289744 WP_003407164.1 NZ_LR882497:1549111-1549932 [Mycobacterium tuberculosis variant microti]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT289744 WP_003407167.1 NZ_LR882497:1549925-1550161 [Mycobacterium tuberculosis variant microti]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIH2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References