Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1387507..1388195 Replicon chromosome
Accession NZ_LR882497
Organism Mycobacterium tuberculosis variant microti strain Maus IV isolate human

Toxin (Protein)


Gene name vapC Uniprot ID G0THR7
Locus tag JN995_RS06510 Protein ID WP_003406304.1
Coordinates 1387764..1388195 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0THR6
Locus tag JN995_RS06505 Protein ID WP_003406302.1
Coordinates 1387507..1387767 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN995_RS06485 1383084..1383908 + 825 WP_003900298.1 trehalose ABC transporter permease SugB -
JN995_RS06490 1383913..1385094 + 1182 WP_003406299.1 trehalose ABC transporter ATP-binding protein SugC -
JN995_RS06495 1385171..1386271 - 1101 WP_003406300.1 magnesium/cobalt transporter CorA -
JN995_RS06500 1386442..1387431 + 990 WP_003406301.1 malate dehydrogenase -
JN995_RS06505 1387507..1387767 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 Antitoxin
JN995_RS06510 1387764..1388195 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin Toxin
JN995_RS06515 1388218..1389906 - 1689 WP_003910308.1 PE family protein -
JN995_RS06520 1390074..1391335 + 1262 WP_202582134.1 IS3 family transposase -
JN995_RS06525 1391445..1392305 + 861 WP_003406306.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15873.08 Da        Isoelectric Point: 5.8838

>T289742 WP_003406304.1 NZ_LR882497:1387764-1388195 [Mycobacterium tuberculosis variant microti]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Download         Length: 432 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9918.25 Da        Isoelectric Point: 6.4755

>AT289742 WP_003406302.1 NZ_LR882497:1387507-1387767 [Mycobacterium tuberculosis variant microti]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THR7

Antitoxin

Source ID Structure
AlphaFold DB G0THR6

References