Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1233873..1234504 Replicon chromosome
Accession NZ_LR882497
Organism Mycobacterium tuberculosis variant microti strain Maus IV isolate human

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag JN995_RS05805 Protein ID WP_003405820.1
Coordinates 1233873..1234184 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag JN995_RS05810 Protein ID WP_003405836.1
Coordinates 1234184..1234504 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN995_RS05785 1229355..1230779 - 1425 WP_003405805.1 class II fumarate hydratase -
JN995_RS05790 1230810..1231898 - 1089 WP_003898726.1 class II fructose-bisphosphatase -
JN995_RS05795 1231954..1232598 + 645 WP_202581996.1 DUF4245 domain-containing protein -
JN995_RS05800 1232605..1233761 - 1157 Protein_1142 AI-2E family transporter -
JN995_RS05805 1233873..1234184 - 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
JN995_RS05810 1234184..1234504 - 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
JN995_RS05815 1234514..1236039 + 1526 Protein_1145 carboxylesterase/lipase family protein -
JN995_RS05820 1236057..1237169 - 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
JN995_RS05825 1237179..1237436 - 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
JN995_RS05830 1237426..1238673 - 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
JN995_RS05835 1238670..1239308 - 639 WP_003898730.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T289740 WP_003405820.1 NZ_LR882497:c1234184-1233873 [Mycobacterium tuberculosis variant microti]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT289740 WP_003405836.1 NZ_LR882497:c1234504-1234184 [Mycobacterium tuberculosis variant microti]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References