289723

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 365046..365689 Replicon chromosome
Accession NZ_LR882497
Organism Mycobacterium tuberculosis variant microti strain Maus IV isolate human

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag JN995_RS01600 Protein ID WP_003401566.1
Coordinates 365264..365689 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag JN995_RS01595 Protein ID WP_003401563.1
Coordinates 365046..365267 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN995_RS01570 360117..360920 - 804 WP_003401540.1 hypothetical protein -
JN995_RS01575 360930..362327 - 1398 WP_003401544.1 sulfatase -
JN995_RS01580 362506..364329 + 1824 WP_105826467.1 PE family protein -
JN995_RS01585 364472..364699 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
JN995_RS01590 364696..364998 + 303 WP_003401560.1 toxin-antitoxin system toxin -
JN995_RS01595 365046..365267 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
JN995_RS01600 365264..365689 + 426 WP_003401566.1 PIN domain nuclease Toxin
JN995_RS01605 365825..366457 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
JN995_RS01610 366454..367362 + 909 WP_202582118.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T289723 WP_003401566.1 NZ_LR882497:365264-365689 [Mycobacterium tuberculosis variant microti]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT289723 WP_003401563.1 NZ_LR882497:365046-365267 [Mycobacterium tuberculosis variant microti]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
AlphaFold DB A0A829CG48

References