289719

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 3800280..3800965 Replicon chromosome
Accession NZ_LR882496
Organism Mycobacterium tuberculosis variant microti strain ATCC 35782 isolate vole

Toxin (Protein)


Gene name vapC Uniprot ID G0TIR9
Locus tag JN993_RS17660 Protein ID WP_003417998.1
Coordinates 3800555..3800965 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JN993_RS17655 Protein ID WP_003912220.1
Coordinates 3800280..3800558 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN993_RS17635 3796269..3797870 - 1602 WP_003417969.1 FAD/NAD(P)-binding protein -
JN993_RS17640 3797887..3798591 - 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
JN993_RS17645 3798709..3799275 - 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
JN993_RS17650 3799337..3800224 + 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
JN993_RS17655 3800280..3800558 + 279 WP_003912220.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JN993_RS17660 3800555..3800965 + 411 WP_003417998.1 type II toxin-antitoxin system VapC family toxin Toxin
JN993_RS17665 3800998..3802734 - 1737 WP_003418002.1 cholesterol oxidase -
JN993_RS17670 3802790..3803917 - 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
JN993_RS17675 3803937..3805526 - 1590 WP_003900682.1 IMP dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-54)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14695.84 Da        Isoelectric Point: 5.1784

>T289719 WP_003417998.1 NZ_LR882496:3800555-3800965 [Mycobacterium tuberculosis variant microti]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10280.75 Da        Isoelectric Point: 10.1819

>AT289719 WP_003912220.1 NZ_LR882496:3800280-3800558 [Mycobacterium tuberculosis variant microti]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGRKRT
LSDVLNEMRDEQ

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIR9

Antitoxin

Source ID Structure

References