289717

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3746000..3746529 Replicon chromosome
Accession NZ_LR882496
Organism Mycobacterium tuberculosis variant microti strain ATCC 35782 isolate vole

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag JN993_RS17420 Protein ID WP_003417760.1
Coordinates 3746272..3746529 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag JN993_RS17415 Protein ID WP_003417757.1
Coordinates 3746000..3746275 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN993_RS17395 3742798..3744235 - 1438 Protein_3435 FAD-binding oxidoreductase -
JN993_RS17400 3744338..3744727 + 390 WP_003417745.1 DUF732 domain-containing protein -
JN993_RS17405 3744741..3745034 - 294 WP_003417749.1 DUF3017 domain-containing protein -
JN993_RS17410 3745031..3745876 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
JN993_RS17415 3746000..3746275 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
JN993_RS17420 3746272..3746529 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
JN993_RS17425 3746571..3747761 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
JN993_RS17430 3747878..3748246 + 369 WP_003417765.1 FHA domain-containing protein -
JN993_RS17435 3748243..3748794 - 552 WP_105799777.1 pentapeptide repeat protein MfpA -
JN993_RS17440 3748801..3749382 - 582 WP_003417769.1 ATP/GTP-binding protein -
JN993_RS17445 3749363..3749731 - 369 WP_003417772.1 DUF742 domain-containing protein -
JN993_RS17450 3749709..3750101 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T289717 WP_003417760.1 NZ_LR882496:3746272-3746529 [Mycobacterium tuberculosis variant microti]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT289717 WP_003417757.1 NZ_LR882496:3746000-3746275 [Mycobacterium tuberculosis variant microti]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
AlphaFold DB G0TI94

References