289714

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3172300..3172987 Replicon chromosome
Accession NZ_LR882496
Organism Mycobacterium tuberculosis variant microti strain ATCC 35782 isolate vole

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag JN993_RS14905 Protein ID WP_003414624.1
Coordinates 3172544..3172987 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag JN993_RS14900 Protein ID WP_003414620.1
Coordinates 3172300..3172557 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN993_RS14880 3167620..3168474 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
JN993_RS14885 3168530..3169693 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
JN993_RS14890 3169710..3170924 - 1215 WP_003414610.1 zinc metalloprotease Rip -
JN993_RS14895 3170932..3172173 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
JN993_RS14900 3172300..3172557 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
JN993_RS14905 3172544..3172987 + 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
JN993_RS14910 3173067..3173729 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
JN993_RS14915 3173825..3174016 + 192 WP_105799616.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
JN993_RS14920 3174348..3176096 + 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
JN993_RS14925 3176192..3176773 + 582 WP_003414644.1 fasciclin domain-containing protein -
JN993_RS14930 3176873..3177139 + 267 WP_031652375.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T289714 WP_003414624.1 NZ_LR882496:3172544-3172987 [Mycobacterium tuberculosis variant microti]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT289714 WP_003414620.1 NZ_LR882496:3172300-3172557 [Mycobacterium tuberculosis variant microti]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure
AlphaFold DB G0TFH0

References