289713

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3166699..3167247 Replicon chromosome
Accession NZ_LR882496
Organism Mycobacterium tuberculosis variant microti strain ATCC 35782 isolate vole

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag JN993_RS14875 Protein ID WP_003414602.1
Coordinates 3166984..3167247 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag JN993_RS14870 Protein ID WP_003414599.1
Coordinates 3166699..3166980 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN993_RS14845 3162322..3163179 - 858 WP_003899513.1 type I methionyl aminopeptidase -
JN993_RS14850 3163221..3163805 - 585 WP_003414585.1 DUF1707 domain-containing protein -
JN993_RS14855 3163909..3164157 + 249 WP_003913411.1 antitoxin VapB23 -
JN993_RS14860 3164154..3164534 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
JN993_RS14865 3164616..3166427 - 1812 WP_003414596.1 penicillin-binding protein -
JN993_RS14870 3166699..3166980 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
JN993_RS14875 3166984..3167247 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN993_RS14880 3167620..3168474 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
JN993_RS14885 3168530..3169693 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
JN993_RS14890 3169710..3170924 - 1215 WP_003414610.1 zinc metalloprotease Rip -
JN993_RS14895 3170932..3172173 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T289713 WP_003414602.1 NZ_LR882496:3166984-3167247 [Mycobacterium tuberculosis variant microti]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT289713 WP_003414599.1 NZ_LR882496:3166699-3166980 [Mycobacterium tuberculosis variant microti]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWP8

References