289710

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3100839..3101409 Replicon chromosome
Accession NZ_LR882496
Organism Mycobacterium tuberculosis variant microti strain ATCC 35782 isolate vole

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag JN993_RS14530 Protein ID WP_003414166.1
Coordinates 3100839..3101195 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag JN993_RS14535 Protein ID WP_003901465.1
Coordinates 3101179..3101409 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN993_RS14510 3096291..3097979 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
JN993_RS14515 3097983..3098309 - 327 WP_003414157.1 hypothetical protein -
JN993_RS14520 3098482..3099069 + 588 WP_003914429.1 DUF3558 family protein -
JN993_RS14525 3099088..3100737 + 1650 WP_105799646.1 CocE/NonD family hydrolase -
JN993_RS14530 3100839..3101195 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
JN993_RS14535 3101179..3101409 - 231 WP_003901465.1 antitoxin MazE Antitoxin
JN993_RS14540 3101452..3102495 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
JN993_RS14545 3102686..3102961 + 276 WP_003911993.1 DUF1778 domain-containing protein -
JN993_RS14550 3103137..3103391 - 255 WP_003917684.1 hypothetical protein -
JN993_RS14555 3103539..3103943 + 405 WP_003414181.1 hypothetical protein -
JN993_RS14560 3103940..3104131 + 192 WP_003414184.1 hypothetical protein -
JN993_RS14565 3104195..3105484 + 1290 Protein_2874 transposase family protein -
JN993_RS14570 3105718..3105975 + 258 WP_003899489.1 hypothetical protein -
JN993_RS14575 3106080..3106391 + 312 WP_003414190.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T289710 WP_003414166.1 NZ_LR882496:c3101195-3100839 [Mycobacterium tuberculosis variant microti]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT289710 WP_003901465.1 NZ_LR882496:c3101409-3101179 [Mycobacterium tuberculosis variant microti]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FBW3

References