289708

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3060855..3061534 Replicon chromosome
Accession NZ_LR882496
Organism Mycobacterium tuberculosis variant microti strain ATCC 35782 isolate vole

Toxin (Protein)


Gene name vapC Uniprot ID P9WF90
Locus tag JN993_RS14310 Protein ID WP_003414059.1
Coordinates 3060855..3061271 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TF64
Locus tag JN993_RS14315 Protein ID WP_003414061.1
Coordinates 3061268..3061534 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN993_RS14290 3056907..3057809 - 903 WP_003900564.1 4-hydroxy-tetrahydrodipicolinate synthase -
JN993_RS14295 3057878..3058630 - 753 WP_003899465.1 FAD-dependent thymidylate synthase -
JN993_RS14300 3058874..3059149 - 276 WP_003414055.1 type I restriction endonuclease subunit S -
JN993_RS14305 3059146..3060768 - 1623 WP_003414057.1 type I restriction-modification system subunit M -
JN993_RS14310 3060855..3061271 - 417 WP_003414059.1 type II toxin-antitoxin system toxin ribonuclease C21 Toxin
JN993_RS14315 3061268..3061534 - 267 WP_003414061.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN993_RS14320 3061560..3061955 - 396 WP_003414064.1 type II toxin-antitoxin system VapC family toxin -
JN993_RS14325 3061952..3062221 - 270 WP_003414066.1 type II toxin-antitoxin system VapB family antitoxin -
JN993_RS14330 3062231..3063325 - 1095 WP_003414068.1 restriction endonuclease subunit S -
JN993_RS14335 3063322..3063741 - 420 WP_003414070.1 winged helix-turn-helix domain-containing protein -
JN993_RS14340 3063815..3064294 - 480 WP_003414073.1 dihydrofolate reductase -
JN993_RS14345 3064365..3065165 - 801 WP_003911953.1 thymidylate synthase -
JN993_RS14350 3065321..3066058 + 738 WP_003414079.1 dienelactone hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(16-56)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15773.00 Da        Isoelectric Point: 7.1294

>T289708 WP_003414059.1 NZ_LR882496:c3061271-3060855 [Mycobacterium tuberculosis variant microti]
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA

Download         Length: 417 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9493.77 Da        Isoelectric Point: 7.2783

>AT289708 WP_003414061.1 NZ_LR882496:c3061534-3061268 [Mycobacterium tuberculosis variant microti]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5SV2

Antitoxin

Source ID Structure
AlphaFold DB G0TF64

References