Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
Location | 2922137..2922851 | Replicon | chromosome |
Accession | NZ_LR882496 | ||
Organism | Mycobacterium tuberculosis variant microti strain ATCC 35782 isolate vole |
Toxin (Protein)
Gene name | vapC | Uniprot ID | G0TQK0 |
Locus tag | JN993_RS13490 | Protein ID | WP_003413460.1 |
Coordinates | 2922411..2922851 (+) | Length | 147 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | P9WJ20 |
Locus tag | JN993_RS13485 | Protein ID | WP_003413456.1 |
Coordinates | 2922137..2922424 (+) | Length | 96 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JN993_RS13450 | 2917559..2917804 | + | 246 | WP_003413429.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
JN993_RS13455 | 2917801..2918205 | + | 405 | WP_003413432.1 | type II toxin-antitoxin system VapC family toxin | - |
JN993_RS13460 | 2918422..2919042 | + | 621 | WP_003413441.1 | DUF4178 domain-containing protein | - |
JN993_RS13465 | 2919053..2919547 | + | 495 | WP_003413444.1 | DUF2617 family protein | - |
JN993_RS13470 | 2919544..2919975 | + | 432 | WP_003413445.1 | DUF4247 domain-containing protein | - |
JN993_RS13475 | 2920000..2920458 | + | 459 | WP_193441927.1 | DUF350 domain-containing protein | - |
JN993_RS13480 | 2920455..2922026 | + | 1572 | WP_003899392.1 | polyamine aminopropyltransferase | - |
JN993_RS13485 | 2922137..2922424 | + | 288 | WP_003413456.1 | antitoxin VapB41 | Antitoxin |
JN993_RS13490 | 2922411..2922851 | + | 441 | WP_003413460.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
JN993_RS13495 | 2922872..2923627 | - | 756 | WP_003413464.1 | YebC/PmpR family DNA-binding transcriptional regulator | - |
JN993_RS13500 | 2923760..2924356 | - | 597 | WP_003413465.1 | pyridoxal 5'-phosphate synthase glutaminase subunit PdxT | - |
JN993_RS13505 | 2924364..2925209 | - | 846 | WP_003413466.1 | acyl-CoA thioesterase II | - |
JN993_RS13510 | 2925238..2926137 | - | 900 | WP_003413468.1 | pyridoxal 5'-phosphate synthase lyase subunit PdxS | - |
JN993_RS13515 | 2926265..2926939 | + | 675 | WP_003413471.1 | pyridoxamine 5'-phosphate oxidase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 147 a.a. Molecular weight: 16026.38 Da Isoelectric Point: 6.8599
>T289706 WP_003413460.1 NZ_LR882496:2922411-2922851 [Mycobacterium tuberculosis variant microti]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK
Download Length: 441 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TQK0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BWB8 |