Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2226628..2227214 Replicon chromosome
Accession NZ_LR882496
Organism Mycobacterium tuberculosis variant microti strain ATCC 35782 isolate vole

Toxin (Protein)


Gene name mazF Uniprot ID G0TLY3
Locus tag JN993_RS10280 Protein ID WP_003410010.1
Coordinates 2226628..2226972 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL58
Locus tag JN993_RS10285 Protein ID WP_003410014.1
Coordinates 2226966..2227214 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN993_RS10245 2222334..2222933 + 600 WP_003409989.1 L-lysine exporter -
JN993_RS10250 2223349..2223777 + 429 WP_003409992.1 cellulose-binding protein -
JN993_RS10255 2224003..2224542 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
JN993_RS10260 2225062..2225622 - 561 WP_003410001.1 RES family NAD+ phosphorylase -
JN993_RS10265 2225619..2225960 - 342 WP_003410003.1 DUF2384 domain-containing protein -
JN993_RS10270 2226046..2226303 + 258 WP_003410006.1 hypothetical protein -
JN993_RS10275 2226204..2226539 - 336 WP_003410009.1 dehydrogenase -
JN993_RS10280 2226628..2226972 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 Toxin
JN993_RS10285 2226966..2227214 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family Antitoxin
JN993_RS10290 2227314..2229629 - 2316 WP_003899120.1 cation transporter ATPase CptG -
JN993_RS10295 2229626..2229898 - 273 WP_003410017.1 DUF1490 family protein -
JN993_RS10300 2229951..2230307 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -
JN993_RS10305 2230464..2231231 + 768 WP_003410019.1 hemerythrin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12230.12 Da        Isoelectric Point: 9.8887

>T289695 WP_003410010.1 NZ_LR882496:c2226972-2226628 [Mycobacterium tuberculosis variant microti]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL

Download         Length: 345 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9290.34 Da        Isoelectric Point: 4.3757

>AT289695 WP_003410014.1 NZ_LR882496:c2227214-2226966 [Mycobacterium tuberculosis variant microti]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5HK3
PDB 5HK0
PDB 5HKC

Antitoxin

Source ID Structure
PDB 7WJ0
PDB 7WNR
AlphaFold DB A0A7U4FAW9

References