289694

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2225062..2225960 Replicon chromosome
Accession NZ_LR882496
Organism Mycobacterium tuberculosis variant microti strain ATCC 35782 isolate vole

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag JN993_RS10260 Protein ID WP_003410001.1
Coordinates 2225062..2225622 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag JN993_RS10265 Protein ID WP_003410003.1
Coordinates 2225619..2225960 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN993_RS10230 2220231..2220884 - 654 WP_003409976.1 cutinase Cfp21 -
JN993_RS10235 2220999..2221229 + 231 WP_003409980.1 DUF167 domain-containing protein -
JN993_RS10240 2221314..2222225 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
JN993_RS10245 2222334..2222933 + 600 WP_003409989.1 L-lysine exporter -
JN993_RS10250 2223349..2223777 + 429 WP_003409992.1 cellulose-binding protein -
JN993_RS10255 2224003..2224542 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
JN993_RS10260 2225062..2225622 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
JN993_RS10265 2225619..2225960 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
JN993_RS10270 2226046..2226303 + 258 WP_003410006.1 hypothetical protein -
JN993_RS10275 2226204..2226539 - 336 WP_003410009.1 dehydrogenase -
JN993_RS10280 2226628..2226972 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
JN993_RS10285 2226966..2227214 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
JN993_RS10290 2227314..2229629 - 2316 WP_003899120.1 cation transporter ATPase CptG -
JN993_RS10295 2229626..2229898 - 273 WP_003410017.1 DUF1490 family protein -
JN993_RS10300 2229951..2230307 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T289694 WP_003410001.1 NZ_LR882496:c2225622-2225062 [Mycobacterium tuberculosis variant microti]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT289694 WP_003410003.1 NZ_LR882496:c2225960-2225619 [Mycobacterium tuberculosis variant microti]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAE4

References