Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2199683..2200386 Replicon chromosome
Accession NZ_LR882496
Organism Mycobacterium tuberculosis variant microti strain ATCC 35782 isolate vole

Toxin (Protein)


Gene name mazF Uniprot ID G0TLK7
Locus tag JN993_RS10070 Protein ID WP_003409778.1
Coordinates 2199683..2200012 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TLK8
Locus tag JN993_RS10075 Protein ID WP_003409780.1
Coordinates 2200009..2200386 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN993_RS10050 2196067..2197136 + 1070 Protein_1985 epoxide hydrolase EphB -
JN993_RS10055 2197133..2197648 + 516 WP_003409718.1 flavin reductase family protein -
JN993_RS10060 2197645..2198706 + 1062 WP_003899092.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
JN993_RS10065 2198703..2199473 + 771 WP_003409775.1 SDR family oxidoreductase -
JN993_RS10070 2199683..2200012 - 330 WP_003409778.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JN993_RS10075 2200009..2200386 - 378 WP_003409780.1 type II toxin-antitoxin system antitoxin MazE5 Antitoxin
JN993_RS10080 2200383..2200973 - 591 WP_003409784.1 SEC-C domain-containing protein -
JN993_RS10085 2201028..2202392 + 1365 WP_202589894.1 HNH endonuclease -
JN993_RS10090 2202547..2202999 - 453 WP_003899095.1 lipoprotein -
JN993_RS10095 2203063..2203464 + 402 WP_003409869.1 hypothetical protein -
JN993_RS10100 2203457..2203639 - 183 WP_003409870.1 hypothetical protein -
JN993_RS10105 2203753..2204103 - 351 WP_003409871.1 hypothetical protein -
JN993_RS10110 2204114..2205016 - 903 WP_003409874.1 hypothetical protein -
JN993_RS10115 2205037..2205228 - 192 WP_003409876.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11787.82 Da        Isoelectric Point: 8.5361

>T289690 WP_003409778.1 NZ_LR882496:c2200012-2199683 [Mycobacterium tuberculosis variant microti]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCSR

Download         Length: 330 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13560.07 Da        Isoelectric Point: 5.1519

>AT289690 WP_003409780.1 NZ_LR882496:c2200386-2200009 [Mycobacterium tuberculosis variant microti]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLK7

Antitoxin

Source ID Structure
AlphaFold DB G0TLK8

References