289686

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1694559..1695175 Replicon chromosome
Accession NZ_LR882496
Organism Mycobacterium tuberculosis variant microti strain ATCC 35782 isolate vole

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag JN993_RS07845 Protein ID WP_003407593.1
Coordinates 1694858..1695175 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag JN993_RS07840 Protein ID WP_003900349.1
Coordinates 1694559..1694861 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN993_RS07830 1690445..1692292 + 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -
JN993_RS07835 1692293..1694545 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
JN993_RS07840 1694559..1694861 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
JN993_RS07845 1694858..1695175 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
JN993_RS07850 1695172..1696176 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
JN993_RS07855 1696229..1697518 + 1290 WP_003407599.1 serine hydrolase -
JN993_RS07860 1697591..1698364 - 774 WP_003912632.1 class I SAM-dependent methyltransferase -
JN993_RS07865 1698422..1698613 - 192 WP_003407609.1 dodecin family protein -
JN993_RS07870 1698644..1698868 - 225 WP_160522526.1 NUDIX domain-containing protein -
JN993_RS07875 1699138..1700166 + 1029 WP_003407612.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T289686 WP_003407593.1 NZ_LR882496:1694858-1695175 [Mycobacterium tuberculosis variant microti]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT289686 WP_003900349.1 NZ_LR882496:1694559-1694861 [Mycobacterium tuberculosis variant microti]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
AlphaFold DB G0TJ73

References