289685

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1581879..1582534 Replicon chromosome
Accession NZ_LR882496
Organism Mycobacterium tuberculosis variant microti strain ATCC 35782 isolate vole

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FAR1
Locus tag JN993_RS07335 Protein ID WP_003407268.1
Coordinates 1581879..1582280 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag JN993_RS07340 Protein ID WP_003407272.1
Coordinates 1582277..1582534 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN993_RS07320 1577351..1578736 - 1386 WP_003407260.1 cytochrome P450 -
JN993_RS07325 1578814..1579848 + 1035 WP_105799885.1 AraC family transcriptional regulator -
JN993_RS07330 1579894..1581624 - 1731 WP_031653809.1 PE family protein -
JN993_RS07335 1581879..1582280 - 402 WP_003407268.1 type II toxin-antitoxin system VapC family toxin Toxin
JN993_RS07340 1582277..1582534 - 258 WP_003407272.1 ribbon-helix-helix domain-containing protein Antitoxin
JN993_RS07345 1582617..1583576 - 960 WP_003407276.1 alpha/beta hydrolase -
JN993_RS07350 1583601..1584563 - 963 WP_003407279.1 alpha/beta hydrolase -
JN993_RS07355 1584562..1585299 + 738 WP_031647000.1 lysoplasmalogenase -
JN993_RS07360 1585380..1587347 + 1968 WP_105799800.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14894.39 Da        Isoelectric Point: 11.6897

>T289685 WP_003407268.1 NZ_LR882496:c1582280-1581879 [Mycobacterium tuberculosis variant microti]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQGLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT289685 WP_003407272.1 NZ_LR882496:c1582534-1582277 [Mycobacterium tuberculosis variant microti]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FAR1

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References