Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 1027239..1028212 | Replicon | chromosome |
| Accession | NZ_LR882496 | ||
| Organism | Mycobacterium tuberculosis variant microti strain ATCC 35782 isolate vole | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | O05911 |
| Locus tag | JN993_RS04830 | Protein ID | WP_003404756.1 |
| Coordinates | 1027712..1028212 (+) | Length | 167 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | G0TFR4 |
| Locus tag | JN993_RS04825 | Protein ID | WP_003404754.1 |
| Coordinates | 1027239..1027715 (+) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JN993_RS04805 | 1023086..1024357 | - | 1272 | WP_003404747.1 | PPE family protein | - |
| JN993_RS04810 | 1024372..1024671 | - | 300 | WP_003404748.1 | PE family protein | - |
| JN993_RS04815 | 1025115..1026896 | + | 1782 | WP_003404749.1 | BCCT family transporter | - |
| JN993_RS04820 | 1026893..1027150 | + | 258 | WP_003404750.1 | hypothetical protein | - |
| JN993_RS04825 | 1027239..1027715 | + | 477 | WP_003404754.1 | DUF1778 domain-containing protein | Antitoxin |
| JN993_RS04830 | 1027712..1028212 | + | 501 | WP_003404756.1 | GNAT family N-acetyltransferase | Toxin |
| JN993_RS04840 | 1028525..1029844 | - | 1320 | WP_003404757.1 | IS256-like element IS1554 family transposase | - |
| JN993_RS04845 | 1030132..1030713 | + | 582 | WP_105799544.1 | IS607-like element IS1535 family transposase | - |
| JN993_RS04850 | 1030713..1032371 | + | 1659 | WP_105799545.1 | IS607 family element transposase accessory protein TnpB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1026893..1079363 | 52470 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 167 a.a. Molecular weight: 18048.55 Da Isoelectric Point: 7.8659
>T289678 WP_003404756.1 NZ_LR882496:1027712-1028212 [Mycobacterium tuberculosis variant microti]
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD
Download Length: 501 bp
Antitoxin
Download Length: 159 a.a. Molecular weight: 17357.95 Da Isoelectric Point: 11.2467
>AT289678 WP_003404754.1 NZ_LR882496:1027239-1027715 [Mycobacterium tuberculosis variant microti]
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGGSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGGSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG
Download Length: 477 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BSZ2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TFR4 |