289676

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 843821..844530 Replicon chromosome
Accession NZ_LR882496
Organism Mycobacterium tuberculosis variant microti strain ATCC 35782 isolate vole

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JN993_RS03940 Protein ID WP_055368821.1
Coordinates 844102..844530 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TEX4
Locus tag JN993_RS03935 Protein ID WP_003403834.1
Coordinates 843821..844078 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN993_RS03925 840930..842108 + 1179 Protein_776 PE family protein -
JN993_RS03930 842141..843730 + 1590 Protein_777 PE family protein -
JN993_RS03935 843821..844078 + 258 WP_003403834.1 ribbon-helix-helix protein, CopG family Antitoxin
JN993_RS03940 844102..844530 + 429 WP_055368821.1 type II toxin-antitoxin system VapC family toxin Toxin
JN993_RS03945 844620..844794 - 175 Protein_780 transposase -
JN993_RS03950 844907..845152 + 246 WP_003403841.1 hypothetical protein -
JN993_RS03955 845221..846105 - 885 WP_003403844.1 3-hydroxyisobutyrate dehydrogenase -
JN993_RS03960 846116..847288 - 1173 WP_003403845.1 acyl-CoA dehydrogenase FadE9 -
JN993_RS03965 847295..848827 - 1533 WP_003403847.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-133)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15844.27 Da        Isoelectric Point: 7.5536

>T289676 WP_055368821.1 NZ_LR882496:844102-844530 [Mycobacterium tuberculosis variant microti]
MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVNAQPHHL
PTNPGPRHLMLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL

Download         Length: 429 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9114.28 Da        Isoelectric Point: 10.6530

>AT289676 WP_003403834.1 NZ_LR882496:843821-844078 [Mycobacterium tuberculosis variant microti]
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLE
LNSRK

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G0TEX4

References