289672

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 755193..755826 Replicon chromosome
Accession NZ_LR882496
Organism Mycobacterium tuberculosis variant microti strain ATCC 35782 isolate vole

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag JN993_RS03440 Protein ID WP_003403365.1
Coordinates 755193..755576 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag JN993_RS03445 Protein ID WP_003403368.1
Coordinates 755671..755826 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN993_RS03415 750485..751021 + 537 WP_003403341.1 50S ribosomal protein L10 -
JN993_RS03420 751058..751450 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
JN993_RS03425 751443..752138 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
JN993_RS03430 752209..753714 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
JN993_RS03435 753795..754805 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
JN993_RS03440 755193..755576 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
JN993_RS03445 755671..755826 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN993_RS03450 755902..756618 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
JN993_RS03455 756894..757202 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
JN993_RS03460 757189..757434 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
JN993_RS03465 757544..757981 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
JN993_RS03470 757978..758232 - 255 WP_003911263.1 antitoxin VapB7 -
JN993_RS03475 758346..760709 + 2364 WP_105799810.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T289672 WP_003403365.1 NZ_LR882496:c755576-755193 [Mycobacterium tuberculosis variant microti]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT289672 WP_003403368.1 NZ_LR882496:c755826-755671 [Mycobacterium tuberculosis variant microti]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References