289664

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 445582..446593 Replicon chromosome
Accession NZ_LR882496
Organism Mycobacterium tuberculosis variant microti strain ATCC 35782 isolate vole

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag JN993_RS01910 Protein ID WP_003401859.1
Coordinates 445582..446175 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag JN993_RS01915 Protein ID WP_003401860.1
Coordinates 446204..446593 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN993_RS01890 441231..442613 + 1383 WP_105799635.1 magnesium transporter -
JN993_RS01895 442625..443659 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
JN993_RS01900 443755..444438 + 684 WP_003401857.1 VTT domain-containing protein -
JN993_RS01905 444427..445557 - 1131 WP_003401858.1 hypothetical protein -
JN993_RS01910 445582..446175 - 594 WP_003401859.1 zeta toxin family protein Toxin
JN993_RS01915 446204..446593 - 390 WP_003401860.1 hypothetical protein Antitoxin
JN993_RS01920 446674..447885 - 1212 WP_105799636.1 VWA domain-containing protein -
JN993_RS01925 447891..448493 - 603 WP_202589876.1 SRPBCC family protein -
JN993_RS01930 448507..449403 - 897 WP_105799637.1 MoxR family ATPase -
JN993_RS01935 449400..449993 - 594 WP_003401864.1 NTP transferase domain-containing protein -
JN993_RS01940 449990..450745 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T289664 WP_003401859.1 NZ_LR882496:c446175-445582 [Mycobacterium tuberculosis variant microti]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT289664 WP_003401860.1 NZ_LR882496:c446593-446204 [Mycobacterium tuberculosis variant microti]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References