Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4135682..4136502 Replicon chromosome
Accession NZ_LR882493
Organism Escherichia coli isolate 2016-17-292

Toxin (Protein)


Gene name yjhX Uniprot ID B6I030
Locus tag IHO92_RS20265 Protein ID WP_001054379.1
Coordinates 4135682..4135939 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag IHO92_RS20270 Protein ID WP_000123957.1
Coordinates 4135951..4136502 (+) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHO92_RS20245 4130969..4132075 + 1107 WP_001295733.1 N-acetylneuraminate epimerase -
IHO92_RS20250 4132139..4133119 + 981 WP_000991462.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
IHO92_RS20255 4133702..4134928 - 1227 Protein_3961 DNA helicase -
IHO92_RS20260 4135006..4135305 + 300 WP_001332034.1 GNAT family N-acetyltransferase -
IHO92_RS20265 4135682..4135939 + 258 WP_001054379.1 YjhX family toxin Toxin
IHO92_RS20270 4135951..4136502 + 552 WP_000123957.1 N-acetyltransferase Antitoxin
IHO92_RS20275 4136554..4137300 + 747 WP_000354249.1 class I SAM-dependent methyltransferase -
IHO92_RS20280 4137428..4137688 + 261 WP_000077646.1 hypothetical protein -
IHO92_RS20285 4137726..4137842 + 117 Protein_3967 VOC family protein -
IHO92_RS20290 4138087..4139208 + 1122 WP_191519211.1 M42 family metallopeptidase -
IHO92_RS20295 4139205..4139483 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
IHO92_RS20300 4139495..4140808 + 1314 WP_000460845.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimE / fimB 4127103..4144723 17620


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(19-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9568.07 Da        Isoelectric Point: 11.1381

>T289650 WP_001054379.1 NZ_LR882493:4135682-4135939 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 20358.34 Da        Isoelectric Point: 6.4182

>AT289650 WP_000123957.1 NZ_LR882493:4135951-4136502 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Download         Length: 552 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B6I030

Antitoxin

Source ID Structure

References