Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1291388..1292013 Replicon chromosome
Accession NZ_LR882493
Organism Escherichia coli isolate 2016-17-292

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IHO92_RS06275 Protein ID WP_000911330.1
Coordinates 1291615..1292013 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag IHO92_RS06270 Protein ID WP_000450524.1
Coordinates 1291388..1291615 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHO92_RS06245 1287191..1287661 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
IHO92_RS06250 1287661..1288233 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
IHO92_RS06255 1288379..1289257 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
IHO92_RS06260 1289274..1290308 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
IHO92_RS06265 1290521..1291234 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
IHO92_RS06270 1291388..1291615 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
IHO92_RS06275 1291615..1292013 + 399 WP_000911330.1 tRNA(fMet)-specific endonuclease VapC Toxin
IHO92_RS06280 1292160..1293023 + 864 WP_094316634.1 neutral zinc metallopeptidase -
IHO92_RS06285 1293038..1295053 + 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
IHO92_RS06290 1295127..1295825 + 699 WP_000679823.1 esterase -
IHO92_RS06295 1295935..1296135 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T289642 WP_000911330.1 NZ_LR882493:1291615-1292013 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT289642 WP_000450524.1 NZ_LR882493:1291388-1291615 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References