Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 855610..856264 Replicon chromosome
Accession NZ_LR882493
Organism Escherichia coli isolate 2016-17-292

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag IHO92_RS04200 Protein ID WP_000244777.1
Coordinates 855857..856264 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag IHO92_RS04195 Protein ID WP_000354046.1
Coordinates 855610..855876 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHO92_RS04170 850898..851641 + 744 WP_000951948.1 SDR family oxidoreductase -
IHO92_RS04175 851698..853131 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
IHO92_RS04180 853176..853487 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
IHO92_RS04185 853651..854310 + 660 WP_000250274.1 hemolysin III family protein -
IHO92_RS04190 854387..855367 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
IHO92_RS04195 855610..855876 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
IHO92_RS04200 855857..856264 + 408 WP_000244777.1 toxin CptA Toxin
IHO92_RS04205 856304..856825 - 522 WP_001055874.1 flavodoxin FldB -
IHO92_RS04210 856937..857833 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
IHO92_RS04215 857858..858568 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IHO92_RS04220 858574..860307 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T289639 WP_000244777.1 NZ_LR882493:855857-856264 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT289639 WP_000354046.1 NZ_LR882493:855610-855876 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References