Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1986..2533 Replicon plasmid 2
Accession NZ_LR882058
Organism Escherichia coli isolate 2014-01-7375

Toxin (Protein)


Gene name parE Uniprot ID E9LLH3
Locus tag IHP09_RS24060 Protein ID WP_000969996.1
Coordinates 2252..2533 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag IHP09_RS24055 Protein ID WP_032181987.1
Coordinates 1986..2255 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHP09_RS24050 46..1077 + 1032 WP_044706701.1 replication initiation protein -
IHP09_RS24055 1986..2255 + 270 WP_032181987.1 hypothetical protein Antitoxin
IHP09_RS24060 2252..2533 + 282 WP_000969996.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IHP09_RS24065 2573..3421 + 849 WP_001057996.1 3'-5' exonuclease -
IHP09_RS24070 3538..4011 + 474 WP_077128838.1 hypothetical protein -
IHP09_RS24075 4488..4754 - 267 WP_000627831.1 hypothetical protein -
IHP09_RS24080 4754..5248 - 495 WP_001350009.1 hypothetical protein -
IHP09_RS24085 5304..5906 - 603 WP_045133169.1 proQ/FINO family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..98997 98997


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10893.57 Da        Isoelectric Point: 8.4615

>T289624 WP_000969996.1 NZ_LR882058:2252-2533 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10177.47 Da        Isoelectric Point: 6.7251

>AT289624 WP_032181987.1 NZ_LR882058:1986-2255 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVEQQHNTWFRDQVAAGRQQLEHGDVLPHDMVESSATAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9LLH3

Antitoxin

Source ID Structure

References