Detailed information of TA system TA028962

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2513417..2514016
• Replicon: chromosome
• Accession: NC_020286
• Organism: Synechocystis sp. PCC 6803

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MYO_RS11745
• Protein ID: WP_010873447.1
• Coordinates: 2513417..2513794 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MYO_RS11750
• Protein ID: WP_010873448.1
• Coordinates: 2513795..2514016 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYO_RS11730	2508781..2509476	-	696	WP_010873444.1	aldehyde oxygenase (deformylating)	-
MYO_RS11735	2509734..2510831	-	1098	WP_014407137.1	glucose-1-phosphate thymidylyltransferase	-
MYO_RS11740	2511073..2513241	+	2169	WP_010873446.1	glycine--tRNA ligase subunit beta	-
MYO_RS11745	2513417..2513794	-	378	WP_010873447.1	type II toxin-antitoxin system VapC family toxin	Toxin
MYO_RS11750	2513795..2514016	-	222	WP_010873448.1	DUF2281 domain-containing protein	Antitoxin
MYO_RS11755	2514081..2515451	-	1371	WP_010873449.1	FADH(2)-oxidizing methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))- methyltransferase TrmFO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• VapC-like Sll0205 protein, PIN domain (2-124)

Antitoxin

• Domain of unknown function DUF2281 (6-72)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14761.18 Da
• Isoelectric Point: 7.0607

>T28962 WP_010873447.1 NC_020286:c2513794-2513417 [Synechocystis sp. PCC 6803]
MLLDTHTLLWFLDNDIKLPSHLKSLIEAKPKVYVSIVSLWEIAIKLNINKLRLNYAFTDLENLLADLNISVLNITWQHLE
ACRNLPLHHRDPFDRMIIAQAQQHNFSVISKDENFKKYNVNLIWE

Nucleotide

• Length: 378 bp

>T28962 NC_020286:c2513794-2513417 [Synechocystis sp. PCC 6803]
ATGCTACTGGACACCCACACGCTTTTGTGGTTTTTAGATAATGATATAAAACTACCATCACATCTCAAGAGTTTGATTGA
AGCCAAGCCAAAAGTTTATGTCAGCATTGTATCTCTCTGGGAGATTGCCATTAAACTCAACATCAACAAACTAAGGCTTA
ATTACGCTTTTACTGATCTAGAGAATTTACTTGCTGATCTCAATATTTCGGTTTTGAACATCACATGGCAACATTTGGAA
GCTTGTCGCAATTTGCCCTTGCATCATCGAGATCCTTTTGACCGTATGATTATTGCCCAGGCTCAGCAACATAATTTTTC
CGTCATTAGCAAAGACGAAAATTTCAAAAAATACAACGTTAATTTAATCTGGGAATGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8355.66 Da
• Isoelectric Point: 4.3855

>AT28962 WP_010873448.1 NC_020286:c2514016-2513795 [Synechocystis sp. PCC 6803]
MTDTALLEKINALPDAMKIEVEHFVEFLLTKQPPVSPVTNDGQKKYRQAGVLKGKIWMADDFDAPLEEMQEYM

Nucleotide

• Length: 222 bp

>AT28962 NC_020286:c2514016-2513795 [Synechocystis sp. PCC 6803]
ATGACAGACACCGCCCTACTAGAAAAGATCAATGCTCTCCCCGATGCCATGAAAATTGAAGTAGAACACTTTGTCGAATT
TCTGCTGACTAAGCAACCACCAGTCAGTCCAGTAACCAATGATGGACAAAAAAAATATCGTCAAGCAGGTGTTCTAAAGG
GGAAAATTTGGATGGCAGATGACTTTGATGCTCCTTTGGAAGAAATGCAGGAGTATATGTAA