Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3670685..3671303 Replicon chromosome
Accession NZ_LR882057
Organism Escherichia coli isolate 2014-01-7375

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag IHP09_RS17800 Protein ID WP_001291435.1
Coordinates 3671085..3671303 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag IHP09_RS17795 Protein ID WP_000344800.1
Coordinates 3670685..3671059 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHP09_RS17785 3665774..3666967 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IHP09_RS17790 3666990..3670139 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
IHP09_RS17795 3670685..3671059 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
IHP09_RS17800 3671085..3671303 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
IHP09_RS17805 3671475..3672026 + 552 WP_000102564.1 maltose O-acetyltransferase -
IHP09_RS17810 3672142..3672612 + 471 WP_000136192.1 YlaC family protein -
IHP09_RS17820 3674112..3675662 + 1551 WP_112044478.1 cyclic-guanylate-specific phosphodiesterase PdeB -
IHP09_RS17825 3675704..3676057 - 354 WP_000878141.1 DUF1428 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T289617 WP_001291435.1 NZ_LR882057:3671085-3671303 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT289617 WP_000344800.1 NZ_LR882057:3670685-3671059 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References