Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2576042..2576680 Replicon chromosome
Accession NZ_LR882057
Organism Escherichia coli isolate 2014-01-7375

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag IHP09_RS12405 Protein ID WP_000813794.1
Coordinates 2576504..2576680 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag IHP09_RS12400 Protein ID WP_001270286.1
Coordinates 2576042..2576458 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHP09_RS12380 2571194..2572135 - 942 WP_001251315.1 ABC transporter permease -
IHP09_RS12385 2572136..2573149 - 1014 WP_000220411.1 ABC transporter ATP-binding protein -
IHP09_RS12390 2573167..2574312 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
IHP09_RS12395 2574557..2575963 - 1407 WP_000760629.1 PLP-dependent aminotransferase family protein -
IHP09_RS12400 2576042..2576458 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
IHP09_RS12405 2576504..2576680 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
IHP09_RS12410 2576902..2577132 + 231 WP_000494239.1 YncJ family protein -
IHP09_RS12415 2577224..2579185 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
IHP09_RS12420 2579258..2579794 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
IHP09_RS12425 2579847..2581061 + 1215 WP_001307190.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T289615 WP_000813794.1 NZ_LR882057:c2576680-2576504 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT289615 WP_001270286.1 NZ_LR882057:c2576458-2576042 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References