Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1406422..1407047 Replicon chromosome
Accession NZ_LR882057
Organism Escherichia coli isolate 2014-01-7375

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag IHP09_RS06880 Protein ID WP_000911329.1
Coordinates 1406649..1407047 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag IHP09_RS06875 Protein ID WP_000450524.1
Coordinates 1406422..1406649 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHP09_RS06850 1402224..1402694 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
IHP09_RS06855 1402694..1403266 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
IHP09_RS06860 1403412..1404290 + 879 WP_075862033.1 4-hydroxy-tetrahydrodipicolinate synthase -
IHP09_RS06865 1404307..1405341 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
IHP09_RS06870 1405554..1406267 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
IHP09_RS06875 1406422..1406649 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
IHP09_RS06880 1406649..1407047 + 399 WP_000911329.1 tRNA(fMet)-specific endonuclease VapC Toxin
IHP09_RS06885 1407194..1408057 + 864 WP_001267498.1 neutral zinc metallopeptidase -
IHP09_RS06890 1408072..1410087 + 2016 WP_000829393.1 tRNA cytosine(34) acetyltransferase TmcA -
IHP09_RS06895 1410161..1410859 + 699 WP_000679812.1 esterase -
IHP09_RS06900 1410969..1411169 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T289609 WP_000911329.1 NZ_LR882057:1406649-1407047 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT289609 WP_000450524.1 NZ_LR882057:1406422-1406649 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References