Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 939173..939827 Replicon chromosome
Accession NZ_LR882057
Organism Escherichia coli isolate 2014-01-7375

Toxin (Protein)


Gene name cptA Uniprot ID A0A140N853
Locus tag IHP09_RS04620 Protein ID WP_000244783.1
Coordinates 939420..939827 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag IHP09_RS04615 Protein ID WP_000354046.1
Coordinates 939173..939439 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHP09_RS04595 935341..935652 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
IHP09_RS04600 935816..936475 + 660 WP_000250274.1 hemolysin III family protein -
IHP09_RS04605 936598..937578 - 981 WP_000399648.1 IS110-like element IS621 family transposase -
IHP09_RS04610 937950..938930 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
IHP09_RS04615 939173..939439 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
IHP09_RS04620 939420..939827 + 408 WP_000244783.1 protein YgfX Toxin
IHP09_RS04625 939867..940388 - 522 WP_001055874.1 flavodoxin FldB -
IHP09_RS04630 940500..941396 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
IHP09_RS04635 941421..942131 + 711 WP_000715216.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IHP09_RS04640 942137..943870 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 936598..937578 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15962.85 Da        Isoelectric Point: 11.2669

>T289607 WP_000244783.1 NZ_LR882057:939420-939827 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEISLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT289607 WP_000354046.1 NZ_LR882057:939173-939439 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A140N853

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References