Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4098077..4098574 Replicon chromosome
Accession NZ_LR882052
Organism Escherichia coli isolate 2015-01-466

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QREC_RS19645 Protein ID WP_001173343.1
Coordinates 4098077..4098250 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QREC_RS19650 Protein ID WP_000398619.1
Coordinates 4098278..4098574 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QREC_RS19635 4094747..4096204 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
QREC_RS19640 4096441..4097958 + 1518 WP_001295074.1 lysine--tRNA ligase -
QREC_RS19645 4098077..4098250 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QREC_RS19650 4098278..4098574 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QREC_RS19655 4098801..4099073 - 273 WP_000405651.1 N-acetyltransferase -
QREC_RS19660 4099085..4099315 - 231 WP_000371704.1 (4Fe-4S)-binding protein -
QREC_RS19665 4099496..4101127 + 1632 WP_001216477.1 sensor histidine kinase -
QREC_RS19670 4101124..4101843 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T289596 WP_001173343.1 NZ_LR882052:c4098250-4098077 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT289596 WP_000398619.1 NZ_LR882052:c4098574-4098278 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References