Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 15888..16438 Replicon plasmid pMyong2
Accession NC_020276
Organism Mycobacterium yongonense 05-1390

Toxin (Protein)


Gene name mazF Uniprot ID M1FXC4
Locus tag OEM_RS25965 Protein ID WP_015388962.1
Coordinates 15888..16214 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M1FW41
Locus tag OEM_RS25970 Protein ID WP_015388963.1
Coordinates 16211..16438 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEM_RS25940 11117..12208 - 1092 WP_041321642.1 hypothetical protein -
OEM_RS25945 12201..12482 - 282 WP_015388957.1 hypothetical protein -
OEM_RS25950 12475..13125 - 651 WP_041321644.1 AAA family ATPase -
OEM_RS25955 13260..15146 + 1887 WP_015388960.1 hypothetical protein -
OEM_RS26100 15146..15874 + 729 WP_015388961.1 hypothetical protein -
OEM_RS25965 15888..16214 - 327 WP_015388962.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OEM_RS25970 16211..16438 - 228 WP_015388963.1 antitoxin MazE family protein Antitoxin
OEM_RS27680 16539..16721 + 183 WP_015388964.1 hypothetical protein -
OEM_RS25975 16774..17301 - 528 WP_157884960.1 hypothetical protein -
OEM_RS25980 17424..17603 - 180 WP_015388966.1 hypothetical protein -
OEM_RS27685 17841..18017 + 177 WP_157884961.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..18089 18089


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Antitoxin MazE-like

(8-69)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11691.57 Da        Isoelectric Point: 10.0105

>T28956 WP_015388962.1 NC_020276:c16214-15888 [Mycobacterium intracellulare subsp. yongonense 05-1390]
VMRGELWTASGRDYAGKPRPVLVVQDDRFDATDSVTICPLTTNTTGAPLLRIPVQPNASNGLTTPSHIMIDKITTVPRSK
IGQRIGKVSTTEMLQLERGLLVFLGMTG

Download         Length: 327 bp

>T28956 NC_020276:c16214-15888 [Mycobacterium intracellulare subsp. yongonense 05-1390]
GTGATGCGCGGAGAACTTTGGACGGCCTCCGGCCGCGACTACGCCGGCAAACCACGGCCGGTGCTCGTCGTCCAGGACGA
CCGTTTCGACGCCACAGATTCCGTCACAATCTGCCCCCTCACAACCAACACCACGGGTGCACCCCTGCTGCGAATACCCG
TGCAGCCCAACGCCTCCAACGGACTCACAACACCGAGCCACATCATGATCGACAAAATCACCACGGTTCCCAGGTCCAAG
ATCGGCCAGCGCATCGGCAAGGTATCGACCACCGAAATGCTCCAGCTCGAACGCGGCCTACTCGTCTTCCTCGGAATGAC
CGGATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8336.10 Da        Isoelectric Point: 4.7027

>AT28956 WP_015388963.1 NC_020276:c16438-16211 [Mycobacterium intracellulare subsp. yongonense 05-1390]
MANRDINRRVADHRTRLREQGLRPLQIWVPDTRAPGFAAEAHRQSALVAASDSAADDQAFVDAISAFNDEDFDAQ

Download         Length: 228 bp

>AT28956 NC_020276:c16438-16211 [Mycobacterium intracellulare subsp. yongonense 05-1390]
ATGGCCAACCGGGACATCAACAGGCGCGTAGCCGACCACCGAACCCGCCTCCGCGAGCAAGGGCTACGCCCCCTTCAAAT
ATGGGTACCCGACACGCGCGCACCAGGATTCGCCGCCGAAGCTCACCGCCAGTCGGCCCTCGTAGCCGCCTCCGACAGCG
CGGCCGACGACCAGGCGTTTGTGGATGCCATCTCCGCGTTCAACGATGAGGACTTCGACGCCCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M1FXC4

Antitoxin

Source ID Structure
AlphaFold DB A0A1L1V834

References