Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 5454525..5455089 Replicon chromosome
Accession NZ_LR881952
Organism Streptomyces sp. KY70 isolate Streptomyces sp. KY70

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag STRPST75_RS24300 Protein ID WP_076966179.1
Coordinates 5454742..5455089 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag STRPST75_RS24295 Protein ID WP_128848473.1
Coordinates 5454525..5454755 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STRPST75_RS24280 5450532..5451062 - 531 WP_030563750.1 hypothetical protein -
STRPST75_RS24285 5451221..5453797 - 2577 WP_202590841.1 aminopeptidase N -
STRPST75_RS24290 5453922..5454470 + 549 WP_202590840.1 DUF1203 domain-containing protein -
STRPST75_RS24295 5454525..5454755 + 231 WP_128848473.1 ribbon-helix-helix domain-containing protein Antitoxin
STRPST75_RS24300 5454742..5455089 + 348 WP_076966179.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
STRPST75_RS24305 5455189..5456217 - 1029 WP_030563744.1 aspartate-semialdehyde dehydrogenase -
STRPST75_RS24310 5456422..5456943 + 522 WP_030563742.1 sigma-70 family RNA polymerase sigma factor -
STRPST75_RS24315 5456946..5457596 + 651 WP_076966176.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-38)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12796.75 Da        Isoelectric Point: 10.9373

>T289557 WP_076966179.1 NZ_LR881952:5454742-5455089 [Streptomyces sp. KY70]
MRRGDIYLIDFEPVRGSEANKARPALIVSNDGANATVERTERGVLTVVPLTSNTARVFPFQVLLPAAECHLSVDSKAQCE
QVRAVSPQRLRRRIGKAPHQRMTEIDAALRRHLAL

Download         Length: 348 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8381.11 Da        Isoelectric Point: 3.8966

>AT289557 WP_128848473.1 NZ_LR881952:5454525-5454755 [Streptomyces sp. KY70]
MKISVSLPQEDVAFVDEYAAKTDADSRSAVLHAAIELLRASTLEAEYEEAFAEWDKGEDAEFWDRVSGDGLTDAAR

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References