Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 3659457..3660151 Replicon chromosome
Accession NZ_LR881940
Organism Escherichia coli isolate 2015-01-2097

Toxin (Protein)


Gene name ypjF Uniprot ID A0A2A3UTQ9
Locus tag IHP11_RS17690 Protein ID WP_001094399.1
Coordinates 3659457..3659825 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag IHP11_RS17695 Protein ID WP_077249034.1
Coordinates 3659846..3660151 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHP11_RS17670 3654968..3656611 + 1644 WP_001310578.1 fimbrial adhesin EcpD -
IHP11_RS17675 3656580..3657290 + 711 WP_001741242.1 fimbrial chaperone EcpE -
IHP11_RS17680 3657603..3657932 + 330 WP_001303809.1 YkgJ family cysteine cluster protein -
IHP11_RS17685 3658113..3658810 - 698 Protein_3461 IS1-like element IS1A family transposase -
IHP11_RS17690 3659457..3659825 - 369 WP_001094399.1 TA system toxin CbtA family protein Toxin
IHP11_RS17695 3659846..3660151 - 306 WP_077249034.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IHP11_RS17700 3660255..3660899 - 645 WP_000086755.1 hypothetical protein -
IHP11_RS17705 3660918..3661139 - 222 WP_191521655.1 DUF987 domain-containing protein -
IHP11_RS17710 3661202..3661678 - 477 WP_001186773.1 RadC family protein -
IHP11_RS17715 3661694..3662179 - 486 WP_001737493.1 antirestriction protein -
IHP11_RS17720 3662271..3663089 - 819 WP_001234749.1 DUF945 domain-containing protein -
IHP11_RS17725 3663180..3663413 - 234 WP_001117560.1 DUF905 family protein -
IHP11_RS17730 3663484..3663714 - 231 Protein_3470 autotransporter domain-containing protein -
IHP11_RS17735 3663798..3664589 - 792 WP_001405552.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(3-100)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13568.73 Da        Isoelectric Point: 7.7465

>T289550 WP_001094399.1 NZ_LR881940:c3659825-3659457 [Escherichia coli]
MNTLPATISPAAKPCPSPVAVWQMLLTRLLEQHYGLMLSDTPFSDETVIKEHIDAGITLANAVNFLVEKYELVRIDRNGF
TSQVQAPYLTATDILQARKACGLMSRCSYRDVSNIVLSRSRL

Download         Length: 369 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11263.85 Da        Isoelectric Point: 6.0454

>AT289550 WP_077249034.1 NZ_LR881940:c3660151-3659846 [Escherichia coli]
MVGLPYTVTPCSGTRLVQEGNRLYYLADRASITGKFSDAESLKLDVVFPHFISQMESMLTTGEMNPRHAHCFTLYHNGFT
CEADTLGSCGYVYIAIYPTQL

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A3UTQ9

Antitoxin

Source ID Structure

References